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| | Reproductive Hormones made in China (17th Feb 23 at 12:09am UTC) | | Reproductive Hormones made in China 尾-human Chorionic Gonadotropin (尾-hCG) Test Kit (Fluorescence Immunoassay)
Application
It is suitable for quantitative determination of 尾-human chorionic gonadotropin (尾-hCG) in human plasma or whole blood in vitro.
Package
1 test/kit, 5 tests/kit, 10tests/kit,25 tests/kit, 50 tests/kit.
Glossary:
Human chorionic gonadotropin (HCG) is a glycoprotein secreted by trophoblast cells of the placenta. It is composed of 伪 and 尾 dimer glycoproteins. A glycoprotein hormone with a molecular weight of 36700, the 伪 subunit is basically similar to FSH (follicle stimulating hormone), LH (luteinizing hormone) and TSH (thyroid stimulating hormone) secreted by the pituitary gland, so they can cross-react with each other, while the 尾 subunit The structures of the bases vary. In mature women, after the fertilized egg moves into the uterine cavity and implants, an embryo is formed. During the process of development and growth into a fetus, the placental syncytiotrophoblast cells produce a large amount of HCG, which can be excreted into the urine through the maternal blood circulation. At 1 to 2.5 weeks of gestation, HCG levels in serum and urine can rapidly increase, peak at the 8th week of pregnancy, and then drop to moderate levels at the 4th month of pregnancy, and remain at the end of pregnancy.
Clinical Significance
1. Application in early pregnancy diagnosis and monitoring of fetal growth and development
2. Application in early diagnosis of tubal pregnancy and monitoring of conservative treatment effect
3. Application in early diagnosis and treatment of gestational trophoblastic disease
4. Application in prenatal screening
5. Application in pregnancy-induced hypertension
Components
The kit consists of 尾-human chorionic membrane promoting support detection reagent card, detection buffer, ID card and instructions.
Beta-human chorionic gonadotropin (beta-hCG)
Human chorionic gonadotropin is a glycoprotein secreted by placental trophoblast cells and consists of alpha and beta dimerized glycoproteins. Human chorionic gonadotropin (HCG) 伪尾 is synthesized by syncytiotrophoblasts.
A glycoprotein hormone with a molecular weight of 36700, the 伪 subunit is basically similar to FSH (follicle stimulating hormone), LH (luteinizing hormone) and TSH (thyroid stimulating hormone) secreted by the pituitary gland, so they can cross-react with each other, while the 尾 subunit The structures of the bases vary. 尾-HCG is structurally similar to 尾-LH, but the last 24 amino acid extension is absent in 尾-LH.
Reference
The absolute value of serum HCG varies greatly in different stages of pregnancy and between pregnant women. Generally, the blood HCG of non-pregnant women is less than 100mIU/mL. The serum HCG level during pregnancy is shown in the following table.
In the first 3 months of pregnancy, the level of HCG approximately doubles every (2.2卤0.5) days, urine HCG (HCG semi-quantitative method) is L in non-pregnant women, >5000 mIU/mL at 40 days of pregnancy, > 60~70 days of pregnancy > (8~32)脳104 mIU/mL (Urine HCG level was the highest in the morning, close to serum level).
Table Serum HCG Levels During Pregnancy (from Implantation Time)
gestational weeksHCG(mIU/mL)
0.2~15~50
1~2 50~500
2~3 100~5000
3~4 500~10000
4~51000~50000
5~6 10000~100000
6~8 15000~200000
Function of Human Chorionic Gonadotropin:
(1) It has the functions of FSH and LH, maintains the lifespan of the menstrual corpus luteum, and increases the menstrual corpus luteum into a pregnancy corpus luteum;
(2) Promote the aromatization of androgens into estrogens, while stimulating the formation of progesterone;
(3) Inhibit the stimulatory effect of phytohemagglutinin on lymphocytes, and human chorionic gonadotropin can be adsorbed on the surface of trophoblasts to prevent embryonic trophoblast cells from being attacked by maternal lymphocytes;
(4) LH-like function, before the fetal pituitary secretes LH, it stimulates the fetal testis to secrete testosterone to promote male sexual differentiation; it can also promote gonadal development, stimulate the vitality of testicular interstitial cells for males, and increase the secretion of male hormone (testosterone). . It is of great significance for the treatment of male patients with pituitary defects, which can not only promote the development of gonadal glands and the secretion of androgen, but also promote the development of secondary sexual characteristics.
(5) Can bind to TSH receptors of maternal thyroid cells to stimulate thyroid activityReproductive Hormones made in China
website:http://www.modaivds.com/all-poct-products/reproductive-hormones/ | |
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